Publication

• Rice Endoplasmic Protein-Derived Peptides, Rice-Ghretropins A and B, Stimulate Ghrelin Release in MGN3-1 Cells and Increase Plasma Acylated Ghrelin and Food Intake in Mice. Kentaro Kaneko, Yuki Tokuyama, Eriko Taniguchi, Shimon Abe, Junya Nakato, Hiroshi Iwakura, Masaru Sato, Atsushi Kurabayashi, Hideyuki Suzuki, Akira Ito, Yuki Higuchi, Ryoko Nakayama, Kimiko Uchiyama, Hajime Takahashi, Kousaku Ohinata. Journal of agricultural and food chemistry 71(1) 421-429 2023年.
• d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice. Yermek Rakhat, Kentaro Kaneko, Lei Wang, Wanxin Han, Yutaka Seino, Daisuke Yabe, Toshihiko Yada. Nutrients 14(15) 2022年.
• D-Allulose cooperates with glucagon-like peptide-1 and activates proopiomelanocortin neurons in the arcuate nucleus and central injection inhibits feeding in mice. Rakhat Yermek, Lei Wang, Kentaro Kaneko, Wanxin Han, Yutaka Seino, Daisuke Yabe, Toshihiko Yada. Biochemical and biophysical research communications 613 159-165 2022年.
• An orally active plant Rubisco-derived peptide increases neuronal leptin responsiveness. Kentaro Kaneko, Yukihiro Takekuma, Tsuyoshi Goto, Kousaku Ohinata. Scientific reports 12(1) 8599-8599 2022年.
• Appetite regulation by plant-derived bioactive peptides for promoting health. Kentaro Kaneko. Peptides 144 170608 2021年.
• Rap1 in the VMH regulates glucose homeostasis. Kentaro Kaneko, Hsiao-Yun Lin, Yukiko Fu, Pradip K Saha, Ana B De la Puente-Gomez, Yong Xu, Kousaku Ohinata, Peter Chen, Alexei Morozov, Makoto Fukuda. JCI insight 6(11)　e142545　2021年.
• Wheat‐ghretropins: novel ghrelin‐releasing peptides derived from wheat protein. Kana Tanikawa, Kentaro Kaneko, Shimon Abe, Jyunya Nakato, Yuki Tokuyama, Sayano Odaka, Hiroshi Iwakura, Masaru Sato, Atsushi Kurabayashi, Hideyuki Suzuki, Miki Makita, Hiroyuki Ikemoto, Shigenobu Matsumura, Kazuo Inoue, Kousaku Ohinata. FEBS Open Bio 11(4) 1144-1152 2021年.
• Gut hormone GIP induces inflammation and insulin resistance in the hypothalamus. Yukiko Fu, Kentaro Kaneko, Hsiao-Yun Lin, Qianxing Mo, Yong Xu, Takayoshi Suganami, Peter Ravn, Makoto Fukuda. Endocrinology 161(9) 2020年.
• A combination of dietary fat intake and nicotine exposure enhances CB1 endocannabinoid receptor expression in hypothalamic nuclei in male mice. Tingting Guo, Tomohiro Tanaka, Mami Matsumoto, Kentaro Kaneko, Tomo Unzai, Yohei Ogino, Daisuke Aotani, Toru Kusakabe, Hiroshi Iwakura, Takashi Miyazawa, Kazunobu Sawamoto, Yasuhiko Minokoshi, Hiroaki Masuzaki, Nobuya Inagaki, Kazuwa Nakao. Neuroscience letters 714 134550-134550 2020年.
• Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. Kentaro Kaneko, Yukiko Fu, Hsiao-Yun Lin, Elizabeth L Cordonier, Qianxing Mo, Yong Gao, Ting Yao, Jacqueline Naylor, Victor Howard, Kenji Saito, Pingwen Xu, Siyu S Chen, Miao-Hsueh Chen, Yong Xu, Kevin W Williams, Peter Ravn, Makoto Fukuda. The Journal of clinical investigation 129(9) 3786-3791 2019年.
• Development of ghrelin transgenic mice for elucidation of clinical implication of ghrelin. Daisuke Aotani, Hiroyuki Ariyasu, Satoko Shimazu-Kuwahara, Yoshiyuki Shimizu, Hidenari Nomura, Yoshiteru Murofushi, Kentaro Kaneko, Ryota Izumi, Masaki Matsubara, Hajime Kanda, Michio Noguchi, Tomohiro Tanaka, Toru Kusakabe, Takashi Miyazawa, Kazuwa Nakao. Endocrine journal 64(Suppl.) S31-S33 2017年.
• Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions. Kentaro Kaneko, Pingwen Xu, Elizabeth L Cordonier, Siyu S Chen, Amy Ng, Yong Xu, Alexei Morozov, Makoto Fukuda. Cell reports 16(11) 3003-3015 2016年.
• Orally administered δ opioid agonist peptide rubiscolin-6 stimulates food intake in aged mice with ghrelin resistance. Yuri Miyazaki, Kentaro Kaneko, Shin Iguchi, Takafumi Mizushige, Ryuhei Kanamoto, Masaaki Yoshikawa, Takahiko Shimizu, Kousaku Ohinata. Molecular nutrition & food research 58(10) 2046-52 2014年.
• δ-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Kentaro Kaneko, Takafumi Mizushige, Yuri Miyazaki, Michael Lazarus, Yoshihiro Urade, Masaaki Yoshikawa, Ryuhei Kanamoto, Kousaku Ohinata. American journal of physiology. Regulatory, integrative and comparative physiology 306(4) R265-72 2014年.
• Characterization of Ile-His-Arg-Phe, a novel rice-derived vasorelaxing peptide with hypotensive and anorexigenic activities. Noriyasu Kontani, Ryo Omae, Tomomi Kagebayashi, Kentaro Kaneko, Yuko Yamada, Takafumi Mizushige, Ryuhei Kanamoto, Kousaku Ohinata. Molecular nutrition & food research 58(2) 359-64 2014年.
• Novel orexigenic pathway prostaglandin D2-NPY system–involvement in orally active orexigenic δ opioid peptide. Kentaro Kaneko, Masaaki Yoshikawa, Kousaku Ohinata. Neuropeptides 46(6) 353-7 2012年.
• Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice. Kentaro Kaneko, Michael Lazarus, Chihiro Miyamoto, Yo Oishi, Nanae Nagata, Shuzhang Yang, Masaaki Yoshikawa, Kosuke Aritake, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Urade, Kousaku Ohinata. Molecular nutrition & food research 56(8) 1315-23 2012年.
• Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity. Ayako Oda, Kentaro Kaneko, Takafumi Mizushige, Michael Lazarus, Yoshihiro Urade, Kousaku Ohinata. Journal of neurochemistry 122(2) 356-62 2012年.
• Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice. Yuko Yamada, Aya Muraki, Mariko Oie, Norimasa Kanegawa, Ayako Oda, Yurina Sawashi, Kentaro Kaneko, Masaaki Yoshikawa, Tsuyoshi Goto, Nobuyuki Takahashi, Teruo Kawada, Kousaku Ohinata. American journal of physiology. Endocrinology and metabolism 302(4) E433-40 2012年.
• Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut mu(1)-receptor coupled to 5-HT(1A), D(2), and GABA(B) systems. Kentaro Kaneko, Masashi Iwasaki, Masaaki Yoshikawa, Kousaku Ohinata. American journal of physiology. Gastrointestinal and liver physiology 299(3) G799-805 2010年.
• Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice. Kousaku Ohinata, Kuniko Takagi, Kyoko Biyajima, Kentaro Kaneko, Chihiro Miyamoto, Akihiro Asakawa, Naomi Eguchi, Yoshihiro Urade, Akio Inui, Masaaki Yoshikawa. Prostaglandins & other lipid mediators 90(3-4) 81-4 2009年.

学会発表・講演（2021年～現在）

• 食による視床下部レプチン感受性と肥満の制御
  金子賢太朗
  第４１回日本肥満学会学術総会シンポジウム 16 機能性食品と肥満症を科学する 2021年

受賞歴など

• 2021年12月　公益財団法人ロッテ財団　ロッテ重光学術賞（金子）
• 2021年12月　福井県小浜市　杉田玄白賞 奨励賞（金子）
• 2021年3月　食創会 安藤スポーツ・食文化振興財団　安藤百福賞 発明発見奨励賞（金子）
• 2018年4月　日本内分泌学会　若手研究奨励賞（金子）
• 2017年10月　日本神経内分泌学会　若手研究奨励賞（金子）
• 2017年5月　GPCR研究会　松尾研究奨励賞（金子）
• 2016年8月　日本肥満学会主催アディポサイエンスシンポジウム　若手優秀研究奨励賞（金子）
• 2015年1月　American Heart Association 2014 Postdoctoral Fellowship Award（金子）
• 2014年1月　上原記念生命科学財団　リサーチフェローシップ（金子）
• 2011年4月　日本学術振興会特別研究員　DC　（金子）
• 2009年5月　日本栄養食糧学会大会　トピックス演題（金子）
• 2009年3月　日本農芸化学会大会　トピックス演題（金子）